Fcer2a^Hie

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Species

Mus musculus

Symbol

Fcer2a^Hie

Category

allele

Allele of gene

Fcer2a

Transgenic Constructs

None

Synonyms

None

Description

This allele was first described as having four point mutations: A82T, V87A, S258L, and D301N. The first two mutations are in the most N-terminal of the four homologous repeats of the stalk region and are predicted to form an alpha-helical coiled-coil arrangement on trimerisation. S258L is in a region essential for IgE binding. A later study revealed a fifth point mutation, K131E, that occurs in the stalk region. This allele is found in mice of 129 or NZB origin.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations