Allele/Variant

Tg(TetO-Erbb2)1Lach

Species
Mus musculus
Symbol
Tg(TetO-Erbb2)1Lach
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • TAN
  • TetO-Her2
Description
The transgene consists of the tet operator driving expression of a bicistronic transcript encoding activated rat Erbb2 (Neu), having the Val664Leu missense mutation, and firefly luciferase, the latter translated from an internal ribosome binding sequence (IRES) upstream of its coding sequence. In a mouse bitransgenic for this transgene and a tetracycline transactivator transgene, administration of doxycycline reversibly induces expression of Erbb2 and luciferase in tissues where the transactivator is expressed.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
increased mammary adenocarcinoma incidenceMGI
increased metastatic potentialMGI
mammary gland duct hyperplasiaMGI
premature deathMGI
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Disease Associations