Prg4^tm1Mawa

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Species

Mus musculus

Symbol

Prg4^tm1Mawa

Category

allele

Allele of gene

Prg4

Transgenic Constructs

None

Synonyms

• Prg4^-

Description

The targeting construct was designed to create a Prg4-B-gal fusion protein by substituting lacZ for exon 6. Northern blot and in situ hybridization, however, detected no transcript in livers of mutant mice. RT-PCR of synovial and liver mRNA showed aberrant mRNA splicing from the allele which was thought to create a nonsense mediated mRNA decay.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations