Allele/Variant

Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll

Species
Mus musculus
Symbol
Grxcr1pi-Tg(Eno2-Gabrb3)0370Brll
Category
allele
Allele of gene
Grxcr1
Transgenic Constructs
None
Synonyms
  • pitg370
  • tg-370
Description
This transgene expresses a mouse Gabrb3 gene under the control of the rat neural-specific enolase promoter. Expression was detected in the brain. This line exhibited behavioral defects not seen in other lines, suggesting that insertional inactivation of an endogenous gene was responsible for the phenotype. A non-complementation test demonstrated that the insertional mutation is allelic to pirouette. Further molecular analysis showed that the insertion is located in intron 2, 25 kb downstream of exon 2.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Phenotype
Annotation details
Source
References
abnormal cochlear inner hair cell morphologyMGI
abnormal inner hair cell stereociliary bundle morphologyMGI
abnormal outer hair cell stereociliary bundle morphologyMGI
abnormal type I vestibular cellMGI
absent startle reflexMGI
bidirectional circlingMGI
deafnessMGI
head bobbingMGI
increased or absent threshold for auditory brainstem responseMGI
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Disease Associations