Mtmr2^tm1.1Abol

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Species

Mus musculus

Symbol

Mtmr2^tm1.1Abol

Category

allele

Allele of gene

Mtmr2

Transgenic Constructs

None

Synonyms

• Mtmr2-null^neo
• Mtmr2^-

Description

The floxed region containing exon 4 was excised from Mtmr2^tm1Abol by crossing with CMV-Cre transgenic mice, causing a frameshift from either ATG start site of translation (in exon 1 or exon 3). No mRNAs containing exon 4 or 3' exons could be detected by RT-PCR from tail, brain, muscle, and sciatic nerve from mutants. Western blot analysis showed that protein was absent from brain lysates from mutant animals.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations