Allele/Variant

Matr3Gt(RRR075)Byg

Species
Mus musculus
Symbol
Matr3Gt(RRR075)Byg
Category
allele
Allele of gene
Matr3
Transgenic Constructs
None
Synonyms
  • Matr3Gt-ex13
  • Matr3Gt(pGT0Lxf)1Ucd
Description
The beta-geo cassette inserted into exon 13. 3' RACE analysis of mouse E14.5 brain and heart tissues showed that the long 3' RACE product (the only form detected in brain) is reduced in heterozygous brain, and that both long and short 3' RACE products are reduced in heterozygous heart. While interruption of the 3' end by the gene trap insertion reduced wild-type transcripts in heterozygotes, this was accompanied by the expression of a fusion transcript that may encode a functional or partly functional fusion protein. Western blot analyses of heterozygous heart and brain failed to detect a significant alteration in protein levels but did reveal the presence of the Matrin 3-beta-geo fusion protein in embryonic heart.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations