Allele/Variant

Tg(KRT14-HPV16E7)2304Plam

Species
Mus musculus
Symbol
Tg(KRT14-HPV16E7)2304Plam
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • 2304
  • K14-E7
Description
This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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