Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(KRT14-HPV16E7)2304Plam
- Species
- Mus musculus
- Symbol
- Tg(KRT14-HPV16E7)2304Plam
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- None
- Synonyms
- 2304
- K14-E7
- Description
- This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes.
- Additional Information
- Literature