Allele/Variant

Mmp13tm1Smk

Species
Mus musculus
Symbol
Mmp13tm1Smk
Category
allele
Allele of gene
Mmp13
Transgenic Constructs
None
Synonyms
  • Mmp-13-
  • Mmp13-
Description
A targeting vector was designed to insert a PGK-neo and a stop codon in order to splice out exon 5, which encodes the zinc-binding residues in the catalytic domain. Northern blot of mutant calvariae demonstrated a lack of transcript when an exon 5 probe was used and a barely detectable amount of transcript when using a 5' probe. Western blot showed no protein in cultures of mutant calvariae.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations