Tmprss2^tm1Psn

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Species

Mus musculus

Symbol

Tmprss2^tm1Psn

Category

allele

Allele of gene

Tmprss2

Transgenic Constructs

None

Synonyms

• Tmprss2^-
• Tmprss2^tm1Tsyk

Description

A targeting vector was designed to replace exons 10-13 with a loxP-flanked neo. The deleted exons encode 2 of 3 catalytic residues essential for serine protease activity. Quantitative RT-PCR failed to detect transcript of exons 11 and 13. Mutants expressed only a 20% reduction in transcripts spanning exons 3 and 4 or 5 and 6, however, mutants expressed 80% less transcript of the 3' UTR than wild-type mice. Sequencing revealed that mutant transcripts alternatively splice exon 9 to exon 14.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations