Version: 8.0.0
Date: Tue Jan 28 2025
Iqgap2tm1Vs
MGI:3526416
Allele of Iqgap2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Iqgap2tm1Vs

Species
Mus musculus
Symbol
Iqgap2tm1Vs
Category
allele
Allele of gene
Iqgap2
Transgenic Constructs
None
Synonyms
None
Description
A 36,241 bp genomic fragment spanning exons 18 - 31 was replaced with a PGK-neo cassette via homologous recombination. This resulted in removal of part of the IQ2 and all of the IQ3, IQ4, and GRD motifs. QRT-PCR confirmed the absence of transcript in hepatocytes and immunoblot analysis confirmed the absence of protein in liver, spleen, heart, and kidney lysates. Only in the liver was a modest increase in Iqgap1 expression detected. QRT-PCR analysis did not detect any change in F2rl2 (coding sequence contained within intron 13 of Iqgap2) expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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