Allele/Variant

Cacna1etm1.1Tsch

Species
Mus musculus
Symbol
Cacna1etm1.1Tsch
Category
allele
Allele of gene
Cacna1e
Transgenic Constructs
None
Synonyms
  • Cav2.3-
Description
Crossing Cacna1etm1Tsch mice with a strain expressing Cre ubiquitously resulted in the excision of exon 2, which encodes the first transmembrane segment of domain 1 and the adjacent loop to IS2. RT-PCR analysis revealed a different splice pattern for exon 1 than expected, producing a novel second exon of 204 bp that contained an in-frame stop codon. Western blot analysis of mutant brain microsomal membranes detected no protein expression from any Cacna1e subunit.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations