Allele/Variant

Flt1tm2Msh

Species
Mus musculus
Symbol
Flt1tm2Msh
Category
allele
Allele of gene
Flt1
Transgenic Constructs
None
Synonyms
  • Flt1-TM-TK-
  • VEGFR1(TM-TK)-
Description
A neomycin resistance gene replaced exon 16, encoding the transmembrane domain. No clear bands were seen for exons downstream of exon 15 in RT-PCR analysis, showing that the protein was truncated at the termination codon in exon 15. Mutant lung tissues demonstrated that the 110-kDa endogenous soluble form was present, as it results from a termination in intron 13. Also present was a new truncated form, approximately 120-kDa, detected with an antiserum raised against the amino acid sequence of exon 15.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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