Allele/Variant

Tg(PDGFB-SNCA)4Ema

Species
Mus musculus
Symbol
Tg(PDGFB-SNCA)4Ema
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • line D
  • PDGFbeta-alpha-syn
Description
The transgene contains human platelet derived growth factor, B polypeptide (PDGFB) promoter, an SV40 splice site, 423 bp of human cDNA encoding full length wild-type alpha synuclein (SNCA), and SV40 polyadenylation sequences.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal motor coordination/balance
MGI
abnormal spatial learning
MGI
alpha-synuclein inclusion body
MGI
decreased dopamine level
MGI
impaired coordinationMGI
increased thigmotaxis
MGI
loss of dopaminergic neurons
MGI
neuronal intranuclear inclusions
MGI
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Disease Associations

Association
Disease Qualifier
Disease
Annotation details
Evidence
Source
References
is implicated inLewy body dementia
  • TAS
is implicated inParkinson's disease 1
  • TAS
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