Igf1r^hyft

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Species

Mus musculus

Symbol

Igf1r^hyft

Category

allele

Allele of gene

Igf1r

Transgenic Constructs

None

Synonyms

• line 186

Description

This mutation, which was identified in an ENU mutagenesis screen, is due to a T-to-A transversion in exon 13 that introduces a premature stop codon upstream of the sequence encoding the transmembrane and kinase domains. Western blot analysis of protein extracts from homozygous mutant 18.5 dpc embryos and newborn mice detected no IGF1R protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations