Allele/Variant

Sema3btm1.2Brd

Species
Mus musculus
Symbol
Sema3btm1.2Brd
Category
allele
Allele of gene
Sema3b
Transgenic Constructs
None
Synonyms
  • m2
  • Sema3BBrdm2
Description
Exons 1-6, encoding the first 163 amino acids and ~40% of the SEMA domain, were flanked with loxP sites. An FRT-flanked puromycin resistance cassette was inserted into intron 6. ES cells were transfected with Cre to remove the floxed sequence containine exons 1-6. In situ hybridization of mutant embryos demonstrated lack of expression in rib primordial and regions of the head. RT-PCR showed transcripts from exons 7 and higher, though the transcripts do not have the full-length SEMA domain and therefore result in a functionally null protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

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