Ep300^tm1Pkb

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Species

Mus musculus

Symbol

Ep300^tm1Pkb

Category

allele

Allele of gene

Ep300

Transgenic Constructs

None

Synonyms

• p300^KIX

Description

A floxed neomycin selection cassette was inserted upstream of the exon encoding the KIX domain and the KIX containing exon itself was mutated so that the tyrosine at amino acid residue 630 became alanine, the alanine at residue 634 became glutamine and the tyrosine at residue 638 became alanine (Y630A, A634Q and Y638A). Transient cre expression then excised the selection cassette. Expression and stability of the mutated product were normal.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations