Allele/Variant

Notch3tm1Khan

Species
Mus musculus
Symbol
Notch3tm1Khan
Category
allele
Allele of gene
Notch3
Transgenic Constructs
None
Synonyms
  • Notch3m
Description
Exon 4 was disrupted by the insertion of a neomycin resistance gene. Exon 4 encodes part of the extracellular domain. Northern blot revealed a transcript shorter than wild-type. 5' RACE experiments revealed that the start site for this short transcript was 23bp downstream of the neo in exon 4. Western blot analysis using antibodies raised against the intracellular domain indicated that the allele is a null.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations