Allele/Variant

Tg(Eno2-PSEN1*P117L)1Gae

Species
Mus musculus
Symbol
Tg(Eno2-PSEN1*P117L)1Gae
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • FAD Tg
  • P117L Tg
Description
The rat enolase 2, gamma promoter was used to drive expression of human presenilin 1 with the P117L mutation in neuronal cells. The mutation is located in the predicted small cytoplasmic loop between the TM1 and TM2 domains. Western blot demonstrated that expression of protein from the transgene was two to three times higher than expression of the endogenous mouse Psen1. Widespread and essentially neuron specific expression was confirmed by in situ hybridization and immunohistochemistry.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal neuron differentiationMGI
decreased neuronal precursor cell numberMGI
Showing 1 - 2 of 2 rows
per page

Disease Associations

No data available