Sgk3^tm1Okad

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Species

Mus musculus

Symbol

Sgk3^tm1Okad

Category

allele

Allele of gene

Sgk3

Transgenic Constructs

None

Synonyms

• Sgk3^-
• Sgk3^tm1Efu

Description

A targeting vector was designed to insert a PGK-neo in place of exons 8 and 9, two critical exons for the kinase domain containing the catalytic core, including a lysine residue that is essential for ATP binding. Stop codons were inserted downstream of the exon 8 splice acceptor site. Northern blot showed a marked reduction in transcripts in mutant skin. Western blot did not detect protein in mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations