Fgfr2^tm1Ewj

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Species

Mus musculus

Symbol

Fgfr2^tm1Ewj

Category

allele

Allele of gene

Fgfr2

Transgenic Constructs

None

Synonyms

• Fgfr2^NeoS252W
• Fgfr2^S252Wflox

Description

A targeting vector containing a 755-756 CA to GG substitution resulted in a Ser252Trp mutation in exon IIIa. A floxed neo was inserted into intron IIIa (exon 7). This allele was a hypomorph and either was not expressed or expressed in reduced levels. Expression of alternative transcripts IIIb and IIIc were reduced by 16% to 41% compared to normal transcripts in multiple tissues tested.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations