Version: 8.0.0
Date: Tue Jan 28 2025
Tg(PDGFB-APPSweIndArc)6Lms
MGI:3603942Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(PDGFB-APPSweIndArc)6Lms

Species
Mus musculus
Symbol
Tg(PDGFB-APPSweIndArc)6Lms
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Arc6
Description
These mice express human amyloid protein precursor bearing the Arctic (E22G) mutation, as well as the Swedish (K670N/M671L) and Indiana (V717F) mutations, under control of the human platelet derived growth factor, B polypeptide (PDGFB), promoter. ELISA demonstrated levels of APP and the Beta-secretase-generated C99 fragment, from which amyloid-Beta is cleaved, were lower in this line than Tg(PDGFB-APPSwIND)20Lms in hippocampus sections.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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