Allele/Variant

Tg(Prdx6)153Pgn

Species
Mus musculus
Symbol
Tg(Prdx6)153Pgn
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Prdx6129/SvJ-Tg
Description
The transgene consists of the entire Prdx6 sequence (approximately 10 kB) and 6.6 kB of upstream sequence from the diet-induced atherosclerosis resistant 129X1/SvJ mouse strain. The 129X1/SvJ sequence contains an amino acid variant at position 124 encoding aspartic acid rather than the alanine found in C57BL/6. Southern blot analysis distinguishes between endogenous and transgenic genes. Lines 153 and 105 contained multiple copies of the transgene and were selected for further analysis. Western blot, ELISA and immunohistochemical analysis reveal higher levels of PRDX6 expression in many tissues, especially liver and aorta, than is found in tissues normally expressing the gene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations