Allele/Variant

Nr1i2tm1Sakl

Species
Mus musculus
Symbol
Nr1i2tm1Sakl
Category
allele
Allele of gene
Nr1i2
Transgenic Constructs
None
Synonyms
  • PXR-
  • Pxrtm1Glaxo-Wellcome
Description
A neomycin resistance gene replaced the first coding exon, which includes the first zinc finger of the DNA-binding domain, via homologous recombination. Northern blot and RT-PCR detected transcript ~200 bp shorter than the wild-type transcript, as expected. Sequence analysis revealed that exon 1 was fused to exon 3 in the mutant animal. The truncated transcript was present at reduced levels. If this RNA is translated from a spurious initiation site, the protein is expected to be nonfunctional.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations