Allele/Variant

Prkacatm3Gsm

Species
Mus musculus
Symbol
Prkacatm3Gsm
Category
allele
Allele of gene
Prkaca
Transgenic Constructs
None
Synonyms
  • CalphaR
Description
A W196R mutation was introduced into exon 7 by homolgous recombination. A loxP flanked neomycin resistance gene containing the SV40 polyA sequence was inserted into intron 5. Western blot demonstrated that mutant cells express half of the level of protein as that of wild-type cells. Cre-mediated recombination restores the expression of the mutant transcript containing the point mutation, and expression of the mutant protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations