Allele/Variant

Keap1tm2Mym

Species
Mus musculus
Symbol
Keap1tm2Mym
Category
allele
Allele of gene
Keap1
Transgenic Constructs
None
Synonyms
  • K1-Kd
  • Keap1-kd
Description
A targeting vector was created in which exons 4-6 were floxed with loxP sites. This region encodes the double glycine repeat domain. Excision of these exons is predicted to result in generation of a truncated form incapable of repressing Nfe2l2 activity. This allele has reduced expression of the protein and is hypomorphic.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations