Allele/Variant

Otx2tm2.1Imat

Species
Mus musculus
Symbol
Otx2tm2.1Imat
Category
allele
Allele of gene
Otx2
Transgenic Constructs
None
Synonyms
  • KI-lacZ
  • Otx2-
Description
The locus was disrupted by the insertion of lacZ and a PGK-neo cassette flanked by two loxP sites into the first exon, thereby deleting the first 21 bp of coding sequence. The neomycin cassette was removed by crossing with mice expressing cre recombinase in the germ line. The reporter gene was transcribed as a fusion mRNA composed of the endogenous 5' UTR, lacZ coding region and 3' region of the endogenous locus, and expression was first observed at the distal part of the visceral endoderm in 5.5 dpc embryos.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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