Als2^tm1Jei

---

Species

Mus musculus

Symbol

Als2^tm1Jei

Category

allele

Allele of gene

Als2

Transgenic Constructs

None

Synonyms

• Als2^-
• Als2^tm1Jeo

Description

Exon 3 was replaced with a neomycin resistance gene, allowing ablation of both short and long isoforms. Transcription is still possible from the endogenous promoter, however, protein translation is terminated after the first 14 amino acids, thereby removing all of the functional domains. Western blot failed to detect protein in various tissues of mutants.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations