Version: 8.0.0
Date: Tue Jan 28 2025
H19tm1Jvs
MGI:3612987
Allele of H19
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

H19tm1Jvs

Species
Mus musculus
Symbol
H19tm1Jvs
Category
allele
Allele of gene
H19
Transgenic Constructs
None
Synonyms
  • H19Xba
Description
The locus was replaced with an H19Xba cassette consisting of murine H19 sequence from 4 kb upstream of the transriptional start site to 7.5 kb downstream of the gene which has been modified with the inserion of 2 XbaI linkers into a SacI site at +580 bp in exon 1. The knockin mutation conserves all sequences at the endogenous locus, with the placement of a single loxP site upstream of the gene and a neo-loxP cassette downstream of the gene. Northern blot analysis indicates expression of H19 RNA is reduced to 57% of wild-type in heterozygotes with a maternally inherited mutant allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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