Allele/Variant

Aco1tm1Mwh

Species
Mus musculus
Symbol
Aco1tm1Mwh
Category
allele
Allele of gene
Aco1
Transgenic Constructs
None
Synonyms
  • Irp1-
Description
A gene trap cassette containing an IRESbetageo was introduced into the second intron of the locus. Insertion of the cassette is expected to abrogate the expression of functional protein. The Betageo was flanked with frt sites to allow conditional inactivation of the locus and the frame-shifting exon 3 is flanked with loxP sites. Transcript was not detected by Northern blot of various mutant organs. Protein was detected at 5% of wild-type levels by Western blot analysis, suggesting that the gene trap construct is leaky.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations