Allele/Variant

TgTn(sb-T2/Onc2)6113Njen

Species
Mus musculus
Symbol
TgTn(sb-T2/Onc2)6113Njen
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • T2/Onc2 (6113)
  • T2Onc2(6113)
Description
A concatemer of sleeping beauty transposable elements each consisting of optimized inverted repeat direct repeat sequence specific for sleeping beauty transposase flanking splice acceptor sites (from engrailed-2, these are larger than those in the T2/Onc construct) and poly A signals in both orientations. Between the splice acceptor sites is 5' long terminal repeat sequence from the murine stem cell virus followed by a splice donor site. This construct can create both loss-of-function and gain-of-function mutations. Lines were selected for high copy number and lack of transposable element methylation. In line 6113 the concatemer integrated into the proximal region of chromosome 1.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations