Chrng^{tm1(Chrne)Mknn}

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Species

Mus musculus

Symbol

Chrng^{tm1(Chrne)Mknn}

Category

allele

Allele of gene

Chrng

Transgenic Constructs

None

Synonyms

• AChRgamma^epsilon

Description

A targeting vector was designed to insert a sequence containing the N-terminal 133 amino acids of Chrng fused to 382 amino acids of Chrne, including transmembrane segments 1-4. Mutants lacked endogenous transcripts at birth, however, mutant transcript levels matched levels of other cholinergic receptor subunits. Mutant transcript levels then decreased during postnatal development, as expected for regulatory sequences in the endogenous locus.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations