Allele/Variant

Tg(CTSG-PML/RARA)135Ley

Species
Mus musculus
Symbol
Tg(CTSG-PML/RARA)135Ley
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • 135/4
  • hCG-PML-RARalpha
Description
The functional cDNA coding sequence is derived from the breakpoint cluster region 1 (bcr-1) isoform transcript of the PML/RARA fusion gene resulting from the characteristic t(15;17)(q22;q11.2-q12) translocation associated with ~90% of human cases of acute promyelocytic leukemia (APML). Expression is targeted specifically to early myeloid-lineage cells by the promoter and 5' regulatory elements of the human cathepsin G gene. The protein product of the fusion gene retains the DNA binding, dimerization and retinoic acid binding domains of the wild-type retinoic acid receptor alpha (RARalpha) protein under control of the regulatory elements of the PML protein. Transgenic line 135 has integrated 4 copies of the transgene. Southern blot analysis of RT-PCR products demonstrates expression in bone marrow; expression in spleen is at the detection limit of RNase protection analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations