Version: 8.0.0
Date: Tue Jan 28 2025
Cdkn1btm2Kin
MGI:3620550
Allele of Cdkn1b
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Cdkn1btm2Kin

Species
Mus musculus
Symbol
Cdkn1btm2Kin
Category
allele
Allele of gene
Cdkn1b
Transgenic Constructs
None
Synonyms
  • p27S10A
Description
A targeting vector was designed to insert an S10A mutation into exon 1. A neomycin resistance gene that was included in the vector was subsequently removed via cre-mediated excision. Protein was reduced in mutant brain, thymus, spleen and testis compared to wild-type. Protein levels in liver, heart, lung and skeletal muscle were not affected by the mutation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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