Allele/Variant

Lmnatm2Lgf

Species
Mus musculus
Symbol
Lmnatm2Lgf
Category
allele
Allele of gene
Lmna
Transgenic Constructs
None
Synonyms
  • LmnaLCO
Description
A targeting vector was designed to delete the last 150 nucleotides of exon 11 and all of intron 11. The deletion created an in-frame fusion between codon 608 in exon 11 and codon 659 in exon 12. A floxed neo included in the vector was removed via cre-mediated recombination. Northern and Western blot demonstrated that no lamin A was produced. Lamin C was produced at wild-type levels.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations