Version: 8.0.0
Date: Tue Jan 28 2025
Tg(MT2A-TGFBR2)4Rser
MGI:3620964Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(MT2A-TGFBR2)4Rser

Species
Mus musculus
Symbol
Tg(MT2A-TGFBR2)4Rser
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • MT-DNIIR-4
  • MTR4
Description
The transgene contains a truncated human TGFBR2 gene under the control of the human MT2A promoter. The truncated receptor contains the extracellular, transmembrane, and juxtamembrane domains. Most of the cytoplasmic domain including the kinase domain is deleted. This mutant receptor acts as a dominant-negative mutation. The promoter contains four metal responsive elements and a beta-globin TATA element, splice sites, and polyadenylation signal. Five lines, 4, 15, 27, 28, and 30, were generated.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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