Allele/Variant

Ptpn11tm2Bgn

Species
Mus musculus
Symbol
Ptpn11tm2Bgn
Category
allele
Allele of gene
Ptpn11
Transgenic Constructs
None
Synonyms
  • Shp2 Ex2-
Description
A cassette containing a splice acceptor, Beta-gal, and pgk-neo replaced exon 2 of the locus by homologous recombination. Western blot demonstrated that mutant mice expressed only a truncated protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Phenotype
Annotation details
Source
References
disorganized embryonic tissue
MGI
embryonic lethality between implantation and somite formation, complete penetrance
MGI
inner cell mass degeneration
MGI
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Disease Associations