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Date: Fri Dec 13 2024
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Ptpn11
tm2Bgn
MGI:3621004
Allele of
Ptpn11
Mus musculus
Summary
Transgenic Constructs
Genomic Variant Information
Variant Molecular Consequences
Phenotypes
Disease Associations
Allele/Variant
Ptpn11
tm2Bgn
Species
Mus musculus
Symbol
Ptpn11
tm2Bgn
Category
allele
Allele of gene
Ptpn11
Transgenic Constructs
None
Synonyms
Shp2 Ex2
-
Description
A cassette containing a splice acceptor, Beta-gal, and pgk-neo replaced exon 2 of the locus by homologous recombination. Western blot demonstrated that mutant mice expressed only a truncated protein.
Additional Information
Literature
Transgenic Constructs
No data available
Genomic Variant Information
No data available
Variant Molecular Consequences
Phenotypes
Phenotype
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Annotation details
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References
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disorganized embryonic tissue
View
Name
Type
Experimental condition
Modifier
References
Ptpn11
tm2Bgn
/Ptpn11
tm2Bgn
[background:] involves: 129S4/SvJae
genotype
PMID:16516835
MGI
PMID:16516835
embryonic lethality between implantation and somite formation, complete penetrance
View
Name
Type
Experimental condition
Modifier
References
Ptpn11
tm2Bgn
/Ptpn11
tm2Bgn
[background:] involves: 129S4/SvJae
genotype
PMID:16516835
MGI
PMID:16516835
inner cell mass degeneration
View
Name
Type
Experimental condition
Modifier
References
Ptpn11
tm2Bgn
/Ptpn11
tm2Bgn
[background:] involves: 129S4/SvJae
genotype
PMID:16516835
MGI
PMID:16516835
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