Allele/Variant

Tg(Fabp4-Hsd11b1)7Jesf

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

aP2-HSD1

Description

This transgene consists of the rat Hsd11b1 gene under the control of the enhancer-promoter region of the adipocyte fatty acid binding protein (Fabp4) gene. Hsd11b1 transcript is expressed equivalently in adipose tissue from subcutaneous, abdominal, epididymal, mesenteric, and interscapular brown adipose tissue depots but is absent in brain, liver, skeletal muscle and kidney. Hsd11b1 mRNA is increased 7-fold compared to endogenous mRNA and activity is increased 2.4-fold in subcutaneous abdominal fat and 2.7-fold in epididymal fat.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Hsd11b1 (Rno)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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