Trp53^tm2Xu

---

Species

Mus musculus

Symbol

Trp53^tm2Xu

Category

allele

Allele of gene

Trp53

Transgenic Constructs

None

Synonyms

• p53^S18/23A

Description

Site-directed mutagenesis within exon 2 generated missense mutations at codons 18 and 23, resulting in the substitutions of both serines with alanines (p.S18A, p.S23A). A single loxP site remained in intron 4 after a loxP site flanked neomycin resistance gene cassette was excised via Cre-mediated recombination. Sequencing verified that only the S18/23A mutations were present in mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations