Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Ckm-Prkaa2*K45R)1Mbb
MGI:3639284Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Ckm-Prkaa2*K45R)1Mbb

Species
Mus musculus
Symbol
Tg(Ckm-Prkaa2*K45R)1Mbb
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • alpha2 AMPK KD
  • Tg-KD1
Description
This transgene contains the full length cDNA of rat Prkaa2 with the lysine at residue 45 (residue critical for ATP binding and hydrolysis) changed to arginine and tagged at the 5'end with a myc epitope under the control of the muscle creatine kinase promoter. Expression of endogenous Prkaa2 is completely undetectable and transgene expression occurs in skeletal and cardiac muscle.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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