Allele/Variant

Tg(Ckm-Prkaa2*K45R)1Mbb

Species
Mus musculus
Symbol
Tg(Ckm-Prkaa2*K45R)1Mbb
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • alpha2 AMPK KD
  • Tg-KD1
Description
This transgene contains the full length cDNA of rat Prkaa2 with the lysine at residue 45 (residue critical for ATP binding and hydrolysis) changed to arginine and tagged at the 5'end with a myc epitope under the control of the muscle creatine kinase promoter. Expression of endogenous Prkaa2 is completely undetectable and transgene expression occurs in skeletal and cardiac muscle.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal circulating glucose level
MGI
abnormal muscle physiology
MGI
abnormal myocardial fiber morphology
MGI
abnormal response to cardiac infarction
MGI
decreased heart left ventricle muscle contractility
MGI
impaired exercise endurance
MGI
small heart
MGI
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Disease Associations

No data available