Allele/Variant

Hpntm1Qwu

Species
Mus musculus
Symbol
Hpntm1Qwu
Category
allele
Allele of gene
Hpn
Transgenic Constructs
None
Synonyms
  • Tmprss1-
Description
Exons 5-8, which encode the conserved activation site and most of the catalytic domain, were deleted and replaced with a neomycin selection cassette. Northern blot analysis of total liver RNA derived from mutant mice demonstrated that no detectable transcript is expressed from this allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal auditory brainstem response waveform shape
MGI
abnormal cochlear ganglion morphology
MGI
abnormal cochlear inner hair cell physiology
MGI
abnormal cochlear outer hair cell physiology
MGI
abnormal myelination
MGI
abnormal tectorial membrane morphology
MGI
abnormal tectorial membrane striated-sheet matrix morphology
MGI
decreased activity of thyroid gland
MGI
decreased thyroxine level
MGI
enlarged tectorial membrane
MGI
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Disease Associations

No data available