Als2^tm1Hay

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Species

Mus musculus

Symbol

Als2^tm1Hay

Category

allele

Allele of gene

Als2

Transgenic Constructs

None

Synonyms

• Als2^-

Description

A promoter trap strategy was used to replace exons 3 and 4 with an SA-IRES-betageo-pA cassette. The resulting protein encoded from the locus would contain only the five N-terminal amino acids fused to lacZ-neo, thereby inactivating both the full-length and the proposed short form of amyotrophic lateral sclerosis 2 (juvenile) homolog. Absence of protein was confirmed by Western blot analysis of cortex, cerebellum and testis.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations