Allele/Variant

Tg(Pcp2-cre)1Amc

Species
Mus musculus
Symbol
Tg(Pcp2-cre)1Amc
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • L7-Cre
  • L7-deltaAUG Cre
Description
The transgene was generated by placing the L7-deltaAUG promoter enhancer (from the L7-deltaAUG vector in which all upstream ATGs have been mutated) upstream of cre in the pSP-13Cre plasmid. The L7/Pcp2 modified promoter can direct tissue specific expression of genes downstream of it but translation can only be initiated from the ATG of the cre gene downstream of the promoter, resulting in tissue specific expression of cre protein in cerebellar Purkinje cells. (NOTE: A GFP transgene co-integrated with the Tg(Pcp2-cre)1Amc transgene. As such, GFP expression is reported in the cerebellum [personal communication])
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
  • Pcp2
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations