Version: 8.0.0
Date: Tue Jan 28 2025
Tg(PF4-tTA/VP16)42Kra
MGI:3656262Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(PF4-tTA/VP16)42Kra

Species
Mus musculus
Symbol
Tg(PF4-tTA/VP16)42Kra
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • PF4-tTA-VP16
Description
The rat platelet factor 4 (RP4) promoter was cloned into the tTA-containing plasmid, replacing the existing CMV promoter. The promoter will drive expression of the transactivator tTA fused to the viral coactivator VP16. Expression is repressed with administration of doxycycline and is induced by removal of doxycycline from the diet of the mice.The transgene also contains 1.7 kb of the 3'end of the human beta-globin gene including the 3' intron and polyadenylation signal to permit stable RNA production in mice. A stop codon in the transgene prevents translation of beta-globin into the protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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