Allele/Variant

Tg(Myh6-Ngfb)4Fed

Species

Mus musculus

Symbol

Tg(Myh6-Ngfb)4Fed

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

MHC-NGF
Tg(Ngfb)1Fed

Description

This transgene consists of a 654-bp fragment of rat alpha-myosin heavy chain promoter inserted upstream of a chimeric Ngfb mini-gene containing noncoding exon 1 and a portion of intron 1 of the mouse Ngfb gene fused to sequences from intron 3 through exon 4 of the rat Ngfb gene. Northern blots analysis shows cardiac specific expression of Ngfb. Three lines were established (2-4), with line 4 containing 8-10 copies of the transgene and lines 2 and 3 containing between 15 and 20 copies. Line 4 is chosen as a representative line as it continues to exhibit the cardiac pathology due to hypomethylation while lines 2 and 3 are hypermethylated and show loss of the phenotype after propagation for about 10 generations.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype	Annotation details	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Disease Associations

Association	Disease Qualifier	Disease	Annotation details	Evidence	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page