Allele/Variant

Tg(Myh6-Myl2*)21Rbns

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

RLC2v(P-)
TG-RLC(P-)

Description

This transgene consists of the full-length adult mouse (BALB/c) ventricular isoform of Myl2 (regulatory myosin light chain 2) with serines 14, 15, and 19 each mutated and replaced by alanine, under the control of the murine alpha-myosin heavy chain promoter. Replacing the three serines with alanines results in a nonphosphorylatable Myl2. Examination of atrial myofibrillar protein composition shows a progressive replacement of the atrial isoform with the mutated ventricular form as mice age.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Myl2 (Mmu)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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