Allele/Variant

Tg(tetO-EGFR*L858R)56Hev

Species
Mus musculus
Symbol
Tg(tetO-EGFR*L858R)56Hev
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • EGFRL858R
  • L858R56
Description
A mutant human epidermal growth factor receptor (EGFR) cDNA with a T-to-G nucleotide substitution in exon 21 that replaces leucine with arginine at amino acid position 858 (L858R) was cloned between a tetracycline-responsive element and an intron and polyadenylation signal from the mouse protamine 1 gene. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) protein under the control of a tissue-specific promoter can be induced to express the mutant EGFR in tissues or cell types of interest by administration/withdrawal of doxycycline.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

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    Disease Associations

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