Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Myh6-Tnnt2)191Lnwd
- Species
- Mus musculus
- Symbol
- Tg(Myh6-Tnnt2)191Lnwd
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- None
- Description
- This transgene expresses a carboxy-terminal truncated mouse Tnnt2 gene under the control of a rat alpha-myosin heavy chain promoter. The truncation corresponds to a truncation described in familial hypertrophic cardiomyopathy patients in which exons 15 and 16 are missing. This line expresses less than 5% of total Tnnt2 as the mutant transgenic form but expresses slightly more transgene than line 117.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None
Phenotypes
Phenotype | Annotation details | Source | References |
|---|---|---|---|
| abnormal cardiac muscle relaxation | MGI | ||
| abnormal cardiovascular system physiology | MGI | ||
| abnormal heart atrium morphology | MGI | ||
| abnormal myocardial fiber morphology | MGI | ||
| abnormal myocardial fiber physiology | MGI | ||
| decreased cardiac muscle contractility | MGI | ||
| decreased heart weight | MGI | ||
| decreased myocardial fiber number | MGI | ||
| decreased myocardial fiber size | MGI | ||
| dilated heart atrium | MGI |
Disease Associations
Association | Disease Qualifier | Disease | Annotation details | Evidence | Source | References |
|---|---|---|---|---|---|---|
| is implicated in | hypertrophic cardiomyopathy 2 |
|
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