Allele/Variant

Tg(SOD1*H46R*H48Q)58Dbo

Species
Mus musculus
Symbol
Tg(SOD1*H46R*H48Q)58Dbo
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
A 12kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the histidine at position 48 was replaced by glutamine in the encoded protein. This line is the representative line of 10 that developed motor neuron disease before 1 year of age. Lines 73, 67, and 58 show identical pathological changes.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations