Allele/Variant

Tg(Camk2a-cre)10Kmik

Species
Mus musculus
Symbol
Tg(Camk2a-cre)10Kmik
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • TgN(a-CaMKII-nlCre)/10
Description
Expression of bacteriophage P1 Cre recombinase, bearing the nuclear localization signal peptide of SV40 large T antigen, is directed by the promoter of the mouse gene encoding calcium/calmodulin-dependent protein kinase II alpha. Expression of the transgene was demonstrated by RT-PCR analysis, immunoblot analysis and a reporter assay for Cre recombinase activity. Activity is present specifically in the nuclear fraction of the cerebrum, although a low level (1-10% of that in the cerebrum) of "leaky" expression is observed in the cerebellum as well.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations