Htt^tm6Mem

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Species

Mus musculus

Symbol

Htt^tm6Mem

Category

allele

Allele of gene

Htt

Transgenic Constructs

None

Synonyms

• Hdh^neoQ20

Description

This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene and a floxed neo cassette in the promoter. This allele models the number of CAG repeats found in the human Htt and was found to be a hypomorphic allele, expressing reduced levels of the mutant protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations